UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
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Title UMI-tools: Modelling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy Running Title Modelling UMI errors improves quantification accuracy Authors
Unique Molecular Identifiers (UMIs) are random oligonucleotide barcodes that are increasingly used in high-throughout sequencing experiments. Through a UMI, identical copies arising from distinct molecules can be distinguished from those arising through PCR amplification of the same molecule. However, bioinformatic methods to leverage the information from UMIs have yet to be formalised. In part...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2017
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.209601.116